Can Metformin Work With Irregular Cycles

There is inadequate evidence to make a recommendation about the use of metformin for irregular menstrual cycles. Any efficacy in regularising menstruation usually takes at least 5 months. Weight loss has proved more efficient than metformin in restoring menstrual regularity.

The latest PCOS guidelines make the following recommendations regarding the use of metformin for non-conceptional indications:

• Metformin in addition to lifestyle, should be considered in adult women with PCOS with BMI ≥ 25kg/m2 for management of weight and metabolic outcomes.
• Metformin in additional to lifestyle, could be considered in adolescents with a clear diagnosis of PCOS or with symptoms of PCOS before the diagnosis is made.
• Metformin may offer greater benefit in high metabolic risk groups including those with diabetes risk factors, impaired glucose tolerance or high-risk ethnic groups.